Endocrine Abstracts

Background: Yttrium-90 (90Y) pituitary implants have previously been used to treat patients with growth hormone (GH) secreting pituitary adenoma. This study reports the long-term effect of 90Y implants on growth hormone levels and pituitary function in a group of acromegalic patients....

Background: Measurement of mean serum growth hormone (GH) during an oral glucose tolerance test (OGTT) is currently used for determination of disease activity in patients with acromegaly post-treatment. In contrast to normal subjects, GH secretion in acromegalic patients is largely non-pulsatile, even after treatment.Aim: To determine if random serum GH correlated with mean serum GH during OGTT in patients with acromegaly post-treatment. Furthermore, we ...

Background: Controversy exists over the prevalence of colonic neoplasia in individuals with acromegaly. Some previous studies have demonstrated an increased prevalence of colorectal neoplasia compared to controls, however others have shown no such association. Furthermore, colonoscopy in acromegalic individuals has an increased rate of complications and even death....

BackgroundPrevious studies suggest that patients with acromegaly should have regular colonoscopic examinations due to their increased risk of colorectal neoplasia. However, acromegalic patients have significantly enlarged colon and increased rate of complications due to colonoscopy have been reported.AimTo assess the difficulty of performing colonoscopy in acromegalic patients by comparing large bowel length,...